Brand information

Dover
Drotaverine
40 mg
Tablet
(100's pack: ৳ 175.00)
Nipa Pharmaceuticals Ltd.
Reference pricing

Historical package prices

2022
Unit price
৳1.75
100's pack ৳1.75 per unit
৳175.00
Historical reference information These prices are from the 2022 dataset and may not represent current retail prices.

Indications

Spastic conditions of the gastrointestinal tract, irritable bowel syndrome-
  • Biliary colics and spastic conditions of the biliary tract: Cholecystolithiasis, cholecystitis, cholangitis.
  • Renal colics and spastic conditions of the urogenital tract: Nephrolithiasis, ureterolithiasis, pyelitis, cystitis.
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Spastic conditions of the gastrointestinal tract, irritable bowel syndrome-
  • Biliary colics and spastic conditions of the biliary tract: Cholecystolithiasis, cholecystitis, cholangitis.
  • Renal colics and spastic conditions of the urogenital tract: Nephrolithiasis, ureterolithiasis, pyelitis, cystitis.
  • Spastic conditions of the uterus: Dysmenorrhea, imminent abortion, uterine tetanus.

Therapeutic Class

Anticholinergics

Pharmacology

Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.

Dosage

Oral-
  • Adults: 1 to 2 tablets, 3 times daily
  • Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily.
  • Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily.
Injection-
  • Adults: 1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily.
  • For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection.

Interactions

May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.

Contraindications

Drotaverine is contraindicated in patients with known hypersensitivity to the products and its constituents.

Side Effects

The common side effects are headache, dizziness, rhinitis, sinusitis, gastrointestinal upset, nausea, pharyngitis, edema and fatigue.

Pregnancy & Lactation

As with most drugs, the use of Drotaverine Hydrochloride should be avoided during pregnancy and lactation unless essential.

Precautions

Caution should be taken for patients suffering from liver and kidney disease.