Brand information
Synogen
Undenatured Type II Collagen
40 mg
Capsule (Delayed Release)
(30's pack: ৳ 750.00),(20's pack: ৳ 500.00)
Incepta Pharmaceuticals Ltd.
Reference pricing
2022
Historical package prices
Unit price
৳25.00
20's pack
৳25.00 per unit
৳500.00
30's pack
৳25.00 per unit
৳750.00
Historical reference information
These prices are from the
2022
dataset and may not represent current retail prices.
Indications
Undenatured Type II Collagen capsule is indicated for-
- Osteoarthritis
- Rheumatoid arthritis
- Joint pain & inflammation
- Difficulties in flexibility & mobility
- Joint discomfort & stiffness (knee extension)
- Impaired joint function
- Strenuous exercise & sports
Therapeutic Class
Specific mineral preparations
Pharmacology
Undenatured Type II Collagen derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity. Undenatured collagen II has unique mechanism of action. Undenatured collagen II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of undenatured collagen II interact with Peyer’s patches (lymphoid tissue) of small intestine to release collagen-specific regulatory T-cells. Collagen-specific regulatory T-cells then migrate to joint areas and prevent release of T-cells.
Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory cytokines resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding. Undenatured Type II Collagen supports joint function, mobility and flexibilityand also improves knee extension by up to 10% for better range of motion. It also relieves joint pain due to strenuous exercise.
Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory cytokines resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding. Undenatured Type II Collagen supports joint function, mobility and flexibilityand also improves knee extension by up to 10% for better range of motion. It also relieves joint pain due to strenuous exercise.
Dosage
Orally 1 capsule daily with water or as directed by the physician.
Interactions
Not known.
Contraindications
Contraindicated in patients with known hypersensitivity to chicken or egg.
Side Effects
Undenatured Type II Collagen is generally well tolerated in recommended dose. Over dose may cause constipation and headache.
Pregnancy & Lactation
Lack of scientific evidence on the use of undenatured collagen II during pregnancy or lactation.
Storage Conditions
Keep away from direct sunlight and moisture, Store below 30°C temperature in cool and dry place. Keep the medicine out of reach of children.